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MTHFR: It is now possible to address and resolve the root cause of major depressive disorder based on an understanding of its biochemical underpinnings, especially with regards to its genetic cause, primarily what’s called MTHFR polymorphism.  Generally and simply, this minor genetic defect prevents the production of the enzyme that breaks down folate into methylfolate, which is necessary for the normal production and balance of the neurotransmitters: serotonin, norepinephrine, and dopamine.  This genetic deficit also prevents SAM-E and glutathione production and can make homocysteine high, which can exacerbate brain inflammation as a further aggravating factor in depression

APOE: The ApoE gene provides instructions for making a protein called apolipoprotein E. In the brain, ApoE is involved in clearing harmful plaques that form around nerve cells.  These plaques are a hallmark of Alzheimer’s disease and consist of damaged proteins called amyloid β which stick together to form the toxic plaques.   There are at least three slightly different versions (alleles) of the ApoE gene. The major alleles are called E2, E3, and E4. The most common allele is E3, which is found in more than half of the general population.  The E2 form is the most effective at removing Aβ plaque from the brain and subsequently is protective against Alzheimer’s disease. However, the E4 form of the ApoE protein is not very effective at removing Aβ plaque and carries an increased risk of developing Alzheimer’s disease.

Process:

1. Order Test - Genetic tests are mailed directly to you (Please allow 3-7 business days)

2. Swab your mouth 

3. Mail to Certified Lab in a prepaid envelope

Results:

Once your buccal swabs have been received by our accredited 3rd party lab, it normally takes 2-3 weeks for results.